ADAM17

Across TCGA patient cohorts, ADAM17 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAM17-associated genes across cancer lineages are Di-Ras3, ERK2, and Gab2. Each is linked with ADAM17 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADAM17-to-partner and partner-to-ADAM17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Di-Ras3 grouped by ADAM17-low versus ADAM17-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM17→partner) and Y-score (partner→ADAM17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Di-Ras3 →	-0.185	-2.169	<.001	.003	3	3
UCEC	ERK2 →	+0.185	+1.415	.010	.046	3	2
UCEC	Gab2 →	+0.333	+1.765	.013	.014	3	2
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.467	+1.710	.014	.025	3	2
UCEC	Ku80 →	+0.207	+1.778	.019	.008	3	2
UCEC	MEK1 →	+0.526	+2.662	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

Di-Ras3 by ADAM17 expression — UCEC

Explore this box plot interactively →