ADAM17

Across TCGA cell cohorts, ADAM17 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ADAM17-associated genes across cancer lineages are TBATA, MROH2B, and TMEM35A. Each is linked with ADAM17 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADAM17-to-partner and partner-to-ADAM17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBATA grouped by ADAM17-low versus ADAM17-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM17→partner) and Y-score (partner→ADAM17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TBATA →	+0.184	+3.700	<.001	.005	3	1
STOMACH	MROH2B →	+0.017	+4.280	.007	.001	3	1
BLOOD_Leukemia	TMEM35A →	+0.092	+3.607	.005	.004	3	1
BLOOD_Leukemia	RXRG →	+0.160	+4.044	<.001	.001	3	1
BLOOD_Leukemia	ECE2 →	+0.062	+3.007	<.001	.007	3	1
BLOOD_Leukemia	MARCHF10 →	+0.140	+3.409	.003	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

TBATA by ADAM17 expression — OVARY

Explore this box plot interactively →