ADAM11

Across TCGA patient cohorts, ADAM11 mutation is significantly associated with the RNA expression of many other genes, with 1,327 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAM11-associated genes across cancer lineages are DHX38, MIR6839, and COG8. Each is linked with ADAM11 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADAM11-to-partner and partner-to-ADAM11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DHX38 grouped by ADAM11-low versus ADAM11-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM11→partner) and Y-score (partner→ADAM11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	DHX38 →	+0.471	+3.488	.001	.002	3	3
BLCA	MIR6839 →	+0.283	+4.814	<.001	.003	3	3
SKCM	COG8 →	+0.436	+2.031	<.001	.005	3	3
LIHC	MIR6715A →	+0.747	+5.413	<.001	<.001	3	2
LIHC	RNA5SP426 →	+0.402	+4.964	<.001	.002	3	2
LIHC	LINC01745 →	+0.089	+4.647	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,327 associations by consensus.

DHX38 by ADAM11 expression — SKCM

Explore this box plot interactively →