ADAM11

Across TCGA patient cohorts, ADAM11 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAM11-associated genes across cancer lineages are p53, p90 RSK, and eEF2. Each is linked with ADAM11 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADAM11-to-partner and partner-to-ADAM11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p53 grouped by ADAM11-low versus ADAM11-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM11→partner) and Y-score (partner→ADAM11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	p53 →	+0.202	+2.602	.020	.006	3	1
SKCM	p90 RSK →	+0.224	+3.000	.021	.034	3	1
UCEC	eEF2 →	+0.321	+2.999	.029	.035	3	1
UCEC	A-Raf_pS299 →	-0.186	-3.700	<.001	.001	3	1
UCEC	GATA6 →	-0.181	-3.155	.004	.018	3	1
UCEC	JNK2 →	+0.350	+3.594	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

p53 by ADAM11 expression — SKCM

Explore this box plot interactively →