ADAM10

Across TCGA patient cohorts, ADAM10 protein abundance is significantly associated with the RNA expression of many other genes, with 8,753 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ADAM10-associated genes across cancer lineages are RAB11A, CHP1, and RAE1. Each is linked with ADAM10 in more than 4 cancer types. Because this analysis shows association rather than direction, both ADAM10-to-partner and partner-to-ADAM10 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ADAM10 versus RAB11A in COAD, with a Pearson correlation of 0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM10→partner) and Y-score (partner→ADAM10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RAB11A →	+0.521	+0.209	<.001	<.001	3	5
BRCA	CHP1 →	+0.509	+0.525	<.001	<.001	3	5
OV	RAE1 →	-0.723	-0.342	.003	<.001	3	4
COAD	DDX27 →	-0.617	-0.159	<.001	<.001	3	4
COAD	ARPP19 →	+0.425	+0.126	<.001	.005	3	4
OV	DSN1 →	-0.690	-0.381	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,753 associations by consensus.

ADAM10 vs RAB11A — COAD

Explore this scatter interactively →