ADAM10

Across TCGA patient cohorts, ADAM10 mutation is significantly associated with the RNA expression of many other genes, with 4,974 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAM10-associated genes across cancer lineages are ZNF652P1, RNA5SP492, and EDEM1. Each is linked with ADAM10 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADAM10-to-partner and partner-to-ADAM10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF652P1 grouped by ADAM10-low versus ADAM10-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM10→partner) and Y-score (partner→ADAM10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	ZNF652P1 →	+0.033	+5.507	<.001	<.001	3	3
UCEC	RNA5SP492 →	+0.267	+2.244	<.001	.001	3	3
UCEC	EDEM1 →	+0.549	+2.775	<.001	.002	3	3
UCEC	TCF19 →	+0.825	+2.343	<.001	<.001	3	3
COAD	FUT11 →	+0.525	+3.382	.002	.004	3	3
COAD	MIR3908 →	+0.130	+4.412	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,974 associations by consensus.

ZNF652P1 by ADAM10 expression — CESC

Explore this box plot interactively →