ADAM10

Across TCGA cell cohorts, ADAM10 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,101 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ADAM10-associated GO terms across cancer lineages are Viral process, Endosomal transport, and Membrane protein proteolysis. Each is linked with ADAM10 in more than 14 cancer types. Because this analysis shows association rather than direction, both ADAM10-to-partner and partner-to-ADAM10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Viral process grouped by ADAM10-low versus ADAM10-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM10→partner) and Y-score (partner→ADAM10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Viral process →	+0.078	+1.295	<.001	<.001	3	15
BONE	Endosomal transport →	+0.090	+1.550	<.001	<.001	3	15
OESOPHAGUS	Membrane protein proteolysis →	+0.150	+1.667	<.001	<.001	3	15
LARGE_INTESTINE	Regulation of Golgi inheritance →	+0.147	+1.531	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Negative regulation of calcium ion export across plasma membrane →	+0.073	+1.206	<.001	<.001	3	14
OESOPHAGUS	Viral gene expression →	+0.098	+1.210	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,101 associations by consensus.

Viral process by ADAM10 expression — OESOPHAGUS

Explore this box plot interactively →