ADAM10

Across TCGA cell cohorts, ADAM10 mutation is significantly associated with the mutation status of many other genes, with 4,328 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADAM10-associated genes across cancer lineages are MTMR7, LIFR, and TPR. Each is linked with ADAM10 in more than 3 cancer types. Because this analysis shows association rather than direction, both ADAM10-to-partner and partner-to-ADAM10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTMR7 grouped by ADAM10-low versus ADAM10-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM10→partner) and Y-score (partner→ADAM10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MTMR7 →	+5.050	+4.000	.008	.008	1	4
OVARY	LIFR →	+4.415	+4.977	.007	.007	1	4
LARGE_INTESTINE	TPR →	+1.719	+3.807	.001	.001	1	3
LARGE_INTESTINE	SLC25A13 →	+3.415	+3.215	.002	.002	1	3
BLOOD_Leukemia	ARID4B →	+2.728	+3.375	.003	.003	1	3
BLOOD_Lymphoma	PTPRN →	+4.247	+4.554	.001	.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,328 associations by consensus.

MTMR7 by ADAM10 expression — BLOOD_Leukemia

Explore this box plot interactively →