ADAD2

Across TCGA patient cohorts, ADAD2 mutation is significantly associated with the RNA expression of many other genes, with 3,145 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible ADAD2-associated genes across cancer lineages are MLX, MIR769, and H2BC9. Each is linked with ADAD2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADAD2-to-partner and partner-to-ADAD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MLX grouped by ADAD2-low versus ADAD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAD2→partner) and Y-score (partner→ADAD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MLX →	+0.415	+2.856	.003	.001	3	3
UCEC	MIR769 →	+0.263	+2.022	<.001	.006	3	3
SKCM	H2BC9 →	-0.771	-3.807	.006	<.001	3	2
SKCM	PIGW →	+0.394	+3.594	.008	.001	3	2
UCEC	LINC00624 →	+0.742	+3.173	<.001	<.001	3	2
SKCM	ABALON →	+0.543	+2.384	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,145 associations by consensus.

MLX by ADAD2 expression — UCEC

Explore this box plot interactively →