ADAD2

Across TCGA cell cohorts, ADAD2 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,552 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ADAD2-associated GO terms across cancer lineages are Notch signaling pathway, Chemokine (C-C motif) ligand 21 signaling pathway, and L-leucine transport. Each is linked with ADAD2 in more than 5 cancer types. Because this analysis shows association rather than direction, both ADAD2-to-partner and partner-to-ADAD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch signaling pathway grouped by ADAD2-low versus ADAD2-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAD2→partner) and Y-score (partner→ADAD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Notch signaling pathway →	+0.127	+0.744	<.001	.004	3	6
OESOPHAGUS	Chemokine (C-C motif) ligand 21 signaling pathway →	-0.168	-1.480	.002	<.001	3	6
SKIN	L-leucine transport →	+0.088	+0.150	<.001	.009	3	6
SKIN	NMDA selective glutamate receptor signaling pathway →	+0.261	+0.211	<.001	.007	3	5
URINARY_TRACT	Negative regulation of mRNA metabolic process →	+0.064	+0.908	<.001	.001	3	5
OESOPHAGUS	Positive regulation of excitatory synapse assembly →	+1.022	+0.790	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,552 associations by consensus.

Notch signaling pathway by ADAD2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →