ADAD1

Across TCGA patient cohorts, ADAD1 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAD1-associated genes across cancer lineages are ASNS, p62 Lck ligand, and JNK_pT183_Y185. Each is linked with ADAD1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADAD1-to-partner and partner-to-ADAD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by ADAD1-low versus ADAD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAD1→partner) and Y-score (partner→ADAD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.446	+3.807	<.001	<.001	3	3
LUSC	p62 Lck ligand →	+0.695	+2.179	.011	.035	3	2
UCEC	JNK_pT183_Y185 →	-0.173	-2.584	.004	.010	3	2
SKCM	Ku80 →	+0.229	+3.000	.049	.034	3	2
UCEC	MEK1 →	+0.358	+1.584	.006	.019	3	2
UCEC	Mre11 →	-0.069	-2.432	.024	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

ASNS by ADAD1 expression — UCEC

Explore this box plot interactively →