ADA2

Across TCGA pan-cancer cohorts, ADA2 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ADA2 data layer compared with 27 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher ADA2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ADA2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

COAD, HNSC, and LUAD are the cancer types where ADA2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	III,IV	0.799	1.000	.015	36	view →
HNSC	OS	Median	All	1.000	0.484	.038	12	view →
LUAD	DFS	Tertile	II,III,IV	0.822	0.159	.007	11	view →
PDAC	DFS	Quartile	All	0.978	0.762	.008	8	view →
CCRCC	DFS	Median	III,IV	0.567	0.862	.011	4	view →
UCEC	OS	Median	All	0.912	0.987	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ADA2–COAD (DFS)

Open the COAD breakdown →