ADA2

Across TCGA patient cohorts, ADA2 mutation is significantly associated with the RNA expression of many other genes, with 2,637 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADA2-associated genes across cancer lineages are RN7SKP128, MIR6070, and CENPNP1. Each is linked with ADA2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADA2-to-partner and partner-to-ADA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP128 grouped by ADA2-low versus ADA2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADA2→partner) and Y-score (partner→ADA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RN7SKP128 →	+0.053	+3.408	<.001	.002	3	3
SKCM	MIR6070 →	+0.141	+2.139	<.001	.008	3	2
READ	CENPNP1 →	+0.103	+4.533	<.001	.004	3	2
READ	PRELID3BP2 →	+0.250	+5.681	<.001	.001	3	2
LUAD	RN7SL831P →	+0.162	+4.712	<.001	.007	3	2
SKCM	HMGB3P17 →	+0.038	+1.825	.006	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,637 associations by consensus.

RN7SKP128 by ADA2 expression — SKCM

Explore this box plot interactively →