ADA2

Across TCGA patient cohorts, ADA2 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADA2-associated genes across cancer lineages are Cyclin-E1, PKC-delta_pS664, and Rictor_pT1135. Each is linked with ADA2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADA2-to-partner and partner-to-ADA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E1 grouped by ADA2-low versus ADA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADA2→partner) and Y-score (partner→ADA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-E1 →	+0.465	+2.222	.011	.011	3	3
UCEC	PKC-delta_pS664 →	-0.117	-3.321	.021	.009	3	2
UCEC	Rictor_pT1135 →	-0.115	-2.321	.008	.034	3	2
UCEC	eEF2 →	+0.427	+1.700	.004	.044	3	1
UCEC	EGFR_pY1068 →	-0.276	-2.222	.009	.011	3	1
UCEC	eIF4E →	+0.208	+2.222	.019	.011	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Cyclin-E1 by ADA2 expression — UCEC

Explore this box plot interactively →