ADA2

Across TCGA cell cohorts, ADA2 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ADA2-associated genes across cancer lineages are H2BW1, MYOD1, and CBLIF. Each is linked with ADA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADA2-to-partner and partner-to-ADA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H2BW1 grouped by ADA2-low versus ADA2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADA2→partner) and Y-score (partner→ADA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	H2BW1 →	+0.183	+4.977	<.001	.007	3	1
BLOOD_Leukemia	MYOD1 →	+0.015	+3.922	<.001	.002	3	1
BLOOD_Leukemia	CBLIF →	+0.054	+4.091	.006	.002	3	1
BLOOD_Leukemia	CLCA4 →	+0.128	+5.237	<.001	<.001	3	1
BLOOD_Leukemia	NPSR1 →	+0.024	+3.567	<.001	.003	3	1
BLOOD_Leukemia	IGFL1 →	+0.050	+4.091	.003	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

H2BW1 by ADA2 expression — SKIN

Explore this box plot interactively →