Across TCGA patient cohorts, ADA mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADA-associated genes across cancer lineages are 14-3-3_beta, JNK_pT183_Y185, and JNK2. Each is linked with ADA in more than 1 cancer types. Because this analysis shows association rather than direction, both ADA-to-partner and partner-to-ADA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADA→partner) and Y-score (partner→ADA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.106	-2.295	.010	.033	3	1
UCEC	JNK_pT183_Y185 →	-0.192	-3.321	.005	.010	3	1
UCEC	JNK2 →	+0.240	+2.321	.003	.006	3	1
UCEC	MEK1 →	+0.513	+3.700	<.001	.001	3	1
UCEC	MSH2 →	-0.305	-2.295	.001	.033	3	1
UCEC	PDCD4 →	-0.445	-2.321	.022	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Exploration

ADA survival (RNA) · tumor vs normal (RNA) · all ADA data types