ACYP2

Across TCGA pan-cancer cohorts, ACYP2 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of ACYP2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where ACYP2 RNA is repressed in tumor relative to normal tissue. In most cancer types ACYP2 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and LUAD are the cancer types where ACYP2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ACYP2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	II,III,IV	−0.492	<.001	10	view →
THCA	Male	III,IV	−0.758	<.001	9	view →
LUAD	All	III,IV	−0.658	<.001	9	view →
BRCA	All	III,IV	−0.711	<.001	6	view →
BLCA	Male	III,IV	−0.682	.001	6	view →
UCEC	All	All	−0.473	<.001	6	view →
LUSC	Male	II,III,IV	−0.456	<.001	6	view →
HNSC	Male	All	−0.567	.005	4	view →
READ	All	All	−0.267	.041	1	view →
KIRP	Male	All	−0.244	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

ACYP2–KICH

Open the KICH breakdown →