ACYP1

Across TCGA patient cohorts, ACYP1 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACYP1-associated genes across cancer lineages are Lck, 4E-BP1_pT37_T46, and EGFR_pY1068. Each is linked with ACYP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACYP1-to-partner and partner-to-ACYP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lck grouped by ACYP1-low versus ACYP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACYP1→partner) and Y-score (partner→ACYP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Lck →	+0.290	+3.000	.012	.037	3	1
UCEC	4E-BP1_pT37_T46 →	-0.532	-3.000	.014	.036	2	1
UCEC	EGFR_pY1068 →	-0.342	-3.000	.018	.037	1	1
UCEC	PDCD4 →	-0.737	-3.000	.006	.037	1	1
UCEC	TIGAR →	+0.204	+3.026	.020	.019	1	1
UCEC	Bcl-xL →	+0.224	+3.000	.015	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Lck by ACYP1 expression — UCEC

Explore this box plot interactively →