ACVRL1

Across TCGA patient cohorts, ACVRL1 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACVRL1-associated genes across cancer lineages are Caspase-7-cleavedD198, 4E-BP1, and Smac. Each is linked with ACVRL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACVRL1-to-partner and partner-to-ACVRL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ACVRL1-low versus ACVRL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACVRL1→partner) and Y-score (partner→ACVRL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.799	+2.070	<.001	.001	3	2
UCEC	4E-BP1 →	+0.371	+2.459	<.001	<.001	3	2
SKCM	Smac →	+0.342	+2.017	.004	.018	3	2
LUAD	MSH6 →	+0.320	+2.832	.049	.034	3	1
LUAD	Bim →	+0.348	+3.000	.023	.036	3	1
UCEC	EGFR_pY1068 →	-0.226	-1.736	.009	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Caspase-7-cleavedD198 by ACVRL1 expression — UCEC

Explore this box plot interactively →