ACVRL1

Across TCGA cell cohorts, ACVRL1 mutation is significantly associated with the drug of many other genes, with 21 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ACVRL1-associated genes across cancer lineages are Bromosporine, GSK2110183B, and 630600. Each is linked with ACVRL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACVRL1-to-partner and partner-to-ACVRL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Bromosporine grouped by ACVRL1-low versus ACVRL1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACVRL1→partner) and Y-score (partner→ACVRL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Bromosporine →	+0.355	+2.649	.039	.046	3	1
LARGE_INTESTINE	GSK2110183B →	+0.740	+2.649	.014	.046	3	1
LARGE_INTESTINE	630600 →	+0.645	+2.649	.038	.046	3	1
LARGE_INTESTINE	LMP744 →	+0.705	+2.649	.037	.046	3	1
LARGE_INTESTINE	GSK2276186C →	+0.580	+2.649	.011	.046	2	1
LARGE_INTESTINE	50869 →	+0.596	+2.678	.004	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Bromosporine by ACVRL1 expression — LARGE_INTESTINE

Explore this box plot interactively →