ACVR2B

Across TCGA cell cohorts, ACVR2B RNA expression is significantly associated with the go_rna of many other GO terms, with 5,746 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible ACVR2B-associated GO terms across cancer lineages are Negative regulation of gene expression, epigenetic, Epigenetic regulation of gene expression, and Heterochromatin organization. Each is linked with ACVR2B in more than 15 cancer types. Because this analysis shows association rather than direction, both ACVR2B-to-partner and partner-to-ACVR2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of gene expression, epigenetic grouped by ACVR2B-low versus ACVR2B-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ACVR2B→partner) and Y-score (partner→ACVR2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of gene expression, epigenetic →	+0.112	+1.290	<.001	<.001	3	16
STOMACH	Epigenetic regulation of gene expression →	+0.065	+0.893	.001	<.001	3	15
BONE	Heterochromatin organization →	+0.104	+1.268	<.001	<.001	3	15
BONE	Heterochromatin formation →	+0.108	+1.335	<.001	<.001	3	15
BONE	Regulation of DNA repair →	+0.066	+0.982	<.001	<.001	3	14
BONE	Regulation of monoatomic cation transmembrane transport →	-0.107	-1.294	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,746 associations by consensus.

Negative regulation of gene expression, epigenetic by ACVR2B expression — BONE

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