ACVR2B

Across TCGA cell cohorts, ACVR2B mutation is significantly associated with the drug of many other genes, with 15 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ACVR2B-associated genes across cancer lineages are Niraparib, CDK9_5038, and 729189. Each is linked with ACVR2B in more than 1 cancer types. Because this analysis shows association rather than direction, both ACVR2B-to-partner and partner-to-ACVR2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Niraparib grouped by ACVR2B-low versus ACVR2B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACVR2B→partner) and Y-score (partner→ACVR2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Niraparib →	+0.460	+2.678	.008	.037	3	1
LARGE_INTESTINE	CDK9_5038 →	+0.589	+2.906	.032	.033	2	1
LARGE_INTESTINE	729189 →	+0.336	+2.649	.007	.046	2	1
LARGE_INTESTINE	Nutlin-3a (-) →	+0.872	+2.646	.016	.047	1	1
LARGE_INTESTINE	AZD5991 →	+1.228	+2.649	<.001	.046	1	1
LARGE_INTESTINE	GSK2256098C →	+0.425	+2.906	.005	.033	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Niraparib by ACVR2B expression — LARGE_INTESTINE

Explore this box plot interactively →