ACVR2B-AS1

Across TCGA pan-cancer cohorts, ACVR2B-AS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated ACVR2B-AS1 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher ACVR2B-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated ACVR2B-AS1 expression acts as an unfavorable survival marker, although some lineages such as UVM and KIRC show a favorable association.

UVM, KIRC, and BRCA are the cancer types where ACVR2B-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.832	0.388	<.001	140	view →
KIRC	OS	Median	All	0.740	0.537	<.001	101	view →
BRCA	DFS	Tertile	All	0.969	0.915	<.001	89	view →
LUAD	DFS	Median	All	0.754	0.557	<.001	87	view →
LIHC	OS	Median	All	0.383	0.620	<.001	85	view →
ACC	OS	Median	II,III,IV	0.951	0.748	<.001	65	view →
MESO	OS	Tertile	All	0.521	0.233	<.001	47	view →
LGG	DFS	Median	All	0.803	0.666	<.001	36	view →
UCS	DFS	Median	IV	0.909	0.416	.008	30	view →
OV	OS	Tertile	All	0.891	0.792	.016	16	view →
LUSC	OS	Median	All	0.811	0.711	.001	15	view →
COAD	OS	Quartile	IV	0.877	0.194	.006	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

ACVR2B-AS1–UVM (OS)

Open the UVM breakdown →