ACVR1C

Across TCGA patient cohorts, ACVR1C mutation is significantly associated with the RNA expression of many other genes, with 4,701 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACVR1C-associated genes across cancer lineages are RNU6-728P, HAUS1, and DCTN3. Each is linked with ACVR1C in more than 2 cancer types. Because this analysis shows association rather than direction, both ACVR1C-to-partner and partner-to-ACVR1C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-728P grouped by ACVR1C-low versus ACVR1C-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACVR1C→partner) and Y-score (partner→ACVR1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-728P →	+0.175	+4.936	<.001	.003	3	3
UCEC	HAUS1 →	+0.678	+3.091	<.001	<.001	3	3
SKCM	DCTN3 →	+0.343	+2.913	.008	.001	3	3
SKCM	GSTO1 →	+0.872	+3.597	<.001	.001	3	3
HNSC	RNY4P3 →	+0.314	+3.517	<.001	.008	3	2
HNSC	RN7SKP161 →	+0.172	+3.685	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,701 associations by consensus.

RNU6-728P by ACVR1C expression — HNSC

Explore this box plot interactively →