ACVR1C

Across TCGA patient cohorts, ACVR1C mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACVR1C-associated genes across cancer lineages are eEF2, STAT3_pY705, and Caspase-7-cleavedD198. Each is linked with ACVR1C in more than 1 cancer types. Because this analysis shows association rather than direction, both ACVR1C-to-partner and partner-to-ACVR1C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by ACVR1C-low versus ACVR1C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACVR1C→partner) and Y-score (partner→ACVR1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.331	+3.321	.008	.009	3	2
UCEC	STAT3_pY705 →	-0.278	-1.584	.002	.032	3	2
UCEC	Caspase-7-cleavedD198 →	+0.510	+3.827	.015	<.001	3	2
UCEC	Caspase-8 →	-0.240	-2.388	.006	.002	3	2
SKCM	cIAP →	-0.166	-3.144	.011	.018	3	1
UCEC	14-3-3_beta →	-0.075	-2.432	.035	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

eEF2 by ACVR1C expression — UCEC

Explore this box plot interactively →