ACVR1B

Across TCGA pan-cancer cohorts, ACVR1B mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ACVR1B data layer compared with 16 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher ACVR1B mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ACVR1B expression acts as an unfavorable survival marker, although some lineages such as GBM and LSCC show a favorable association.

GBM, CCRCC, and LSCC are the cancer types where ACVR1B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Median	All	0.529	0.222	.011	7	view →
CCRCC	DFS	Tertile	All	0.570	1.000	.024	6	view →
LSCC	DFS	Quartile	All	0.874	0.570	.032	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

ACVR1B–GBM (DFS)

Open the GBM breakdown →