ACVR1

Across TCGA pan-cancer cohorts, ACVR1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ACVR1 data layer compared with 28 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ACVR1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ACVR1 expression acts as an unfavorable survival marker.

UCEC, PDAC, and HNSC are the cancer types where ACVR1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	III,IV	0.280	1.000	.027	12	view →
PDAC	DFS	Median	III,IV	0.498	0.865	.026	12	view →
HNSC	OS	Tertile	III,IV	0.621	0.838	.014	5	view →
GBM	OS	Quartile	All	0.481	0.672	.026	4	view →
LUAD	OS	Quartile	II,III,IV	0.318	0.717	.010	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ACVR1–UCEC (DFS)

Open the UCEC breakdown →