ACVR1

Across TCGA cell cohorts, ACVR1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,650 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ACVR1-associated GO terms across cancer lineages are Epithelial cell fate commitment, Regulation of determination of dorsal identity, and Cardiac muscle cell fate commitment. Each is linked with ACVR1 in more than 16 cancer types. Because this analysis shows association rather than direction, both ACVR1-to-partner and partner-to-ACVR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Epithelial cell fate commitment grouped by ACVR1-low versus ACVR1-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ACVR1→partner) and Y-score (partner→ACVR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Epithelial cell fate commitment →	+0.188	+0.898	<.001	.006	3	17
SOFT_TISSUE	Regulation of determination of dorsal identity →	+0.236	+1.315	<.001	<.001	3	17
OESOPHAGUS	Cardiac muscle cell fate commitment →	+1.737	+1.241	<.001	<.001	3	16
BLOOD_Myeloma	Endocardial cushion fusion →	+1.288	+1.430	<.001	<.001	3	15
BONE	Negative regulation of extrinsic apoptotic signaling pathway →	+0.141	+1.680	<.001	<.001	3	15
LUNG_NSCLC_LUSC	Transforming growth factor beta receptor signaling pathway →	+0.093	+0.930	.003	.007	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,650 associations by consensus.

Epithelial cell fate commitment by ACVR1 expression — BREAST

Explore this box plot interactively →