ACTRT2

Across TCGA patient cohorts, ACTRT2 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACTRT2-associated genes across cancer lineages are STAT3_pY705, Caspase-8, and FASN. Each is linked with ACTRT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACTRT2-to-partner and partner-to-ACTRT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by ACTRT2-low versus ACTRT2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTRT2→partner) and Y-score (partner→ACTRT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	STAT3_pY705 →	-0.266	-2.321	.006	.001	3	2
UCEC	Caspase-8 →	-0.217	-2.880	.014	.001	3	2
UCEC	FASN →	+0.404	+2.222	.003	.010	3	2
UCEC	ACC1 →	+0.336	+1.750	.008	.049	3	2
UCEC	HER3_pY1289 →	+0.067	+2.418	.027	<.001	3	2
UCEC	Rad50 →	-0.237	-2.392	.005	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

STAT3_pY705 by ACTRT2 expression — SKCM

Explore this box plot interactively →