ACTRT2

Across TCGA cell cohorts, ACTRT2 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ACTRT2-associated genes across cancer lineages are SLC17A2, MYH8, and FCN2. Each is linked with ACTRT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACTRT2-to-partner and partner-to-ACTRT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC17A2 grouped by ACTRT2-low versus ACTRT2-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTRT2→partner) and Y-score (partner→ACTRT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SLC17A2 →	+0.006	+4.906	<.001	.006	3	1
OESOPHAGUS	MYH8 →	+0.006	+4.906	<.001	.006	3	1
SKIN	FCN2 →	+0.036	+4.437	<.001	.004	3	1
LUNG_NSCLC_LUAD	OR8A1 →	+0.423	+4.212	<.001	.007	3	1
LUNG_NSCLC_LUAD	IZUMO3 →	+0.043	+4.947	<.001	.001	3	1
LUNG_NSCLC_LUAD	OR8D2 →	+0.075	+4.371	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

SLC17A2 by ACTRT2 expression — OESOPHAGUS

Explore this box plot interactively →