ACTR6

Across TCGA pan-cancer cohorts, ACTR6 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ACTR6 data layer compared with 21 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher ACTR6 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ACTR6 expression acts as an unfavorable survival marker.

LIHC, SKCM, and LUAD are the cancer types where ACTR6 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	All	0.051	0.783	<.001	36	view →
SKCM	DFS	Median	All	0.144	0.739	<.001	24	view →
LUAD	DFS	Median	II,III,IV	0.098	0.682	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

ACTR6–LIHC (OS)

Open the LIHC breakdown →