ACTR6

Across TCGA patient cohorts, ACTR6 mutation is significantly associated with the RNA expression of many other genes, with 319 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACTR6-associated genes across cancer lineages are RPL17P45, RPL35AP3, and MIR6806. Each is linked with ACTR6 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACTR6-to-partner and partner-to-ACTR6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL17P45 grouped by ACTR6-low versus ACTR6-high in OV.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTR6→partner) and Y-score (partner→ACTR6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RPL17P45 →	+0.078	+5.095	<.001	.001	3	2
HNSC	RPL35AP3 →	+0.241	+5.025	<.001	.002	3	2
HNSC	MIR6806 →	+0.723	+5.025	<.001	.002	3	2
LUSC	LINC02629 →	+0.160	+3.438	.004	.006	3	2
OV	RNA5SP410 →	+0.794	+4.238	<.001	.008	3	2
COAD	MIR6075 →	+0.711	+3.717	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 319 associations by consensus.

RPL17P45 by ACTR6 expression — OV

Explore this box plot interactively →