ACTR6

Across TCGA patient cohorts, ACTR6 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACTR6-associated genes across cancer lineages are A-Raf_pS299, PEA-15_pS116, and Src_pY527. Each is linked with ACTR6 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACTR6-to-partner and partner-to-ACTR6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by ACTR6-low versus ACTR6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTR6→partner) and Y-score (partner→ACTR6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.125	-3.000	.024	.036	3	2
UCEC	PEA-15_pS116 →	+0.372	+2.999	.023	.035	3	1
UCEC	Src_pY527 →	-0.423	-2.990	.034	.036	3	1
UCEC	XBP1 →	-0.184	-2.986	.005	.035	3	1
UCEC	ASNS →	+0.456	+3.321	.006	.010	3	1
UCEC	DJ-1 →	+0.154	+2.820	.048	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

A-Raf_pS299 by ACTR6 expression — UCEC

Explore this box plot interactively →