ACTR6

Across TCGA cell cohorts, ACTR6 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ACTR6-associated genes across cancer lineages are MAGEB4, STRA8, and ZNF804B. Each is linked with ACTR6 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACTR6-to-partner and partner-to-ACTR6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by ACTR6-low versus ACTR6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTR6→partner) and Y-score (partner→ACTR6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAGEB4 →	+0.022	+4.415	<.001	.007	3	1
LARGE_INTESTINE	STRA8 →	+0.161	+4.415	<.001	.007	3	1
LARGE_INTESTINE	ZNF804B →	+0.016	+4.415	<.001	.007	3	1
LARGE_INTESTINE	DAZ2 →	+0.252	+4.415	<.001	.007	3	1
BLOOD_Leukemia	MYF6 →	+0.169	+4.705	<.001	.003	3	1
BLOOD_Leukemia	MS4A5 →	+0.061	+4.969	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

MAGEB4 by ACTR6 expression — LARGE_INTESTINE

Explore this box plot interactively →