ACTR3B

Across TCGA patient cohorts, ACTR3B mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACTR3B-associated genes across cancer lineages are eEF2, EGFR_pY1068, and eIF4E. Each is linked with ACTR3B in more than 1 cancer types. Because this analysis shows association rather than direction, both ACTR3B-to-partner and partner-to-ACTR3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by ACTR3B-low versus ACTR3B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTR3B→partner) and Y-score (partner→ACTR3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.392	+2.222	.009	.011	3	1
UCEC	EGFR_pY1068 →	-0.282	-2.584	.008	.010	3	1
UCEC	eIF4E →	+0.200	+3.013	.025	.018	3	1
UCEC	ERK2 →	+0.283	+2.906	<.001	.001	3	1
UCEC	FOXO3a_pS318_S321 →	-0.107	-1.700	.043	.044	3	1
UCEC	GAPDH →	+0.534	+2.459	.019	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

eEF2 by ACTR3B expression — UCEC

Explore this box plot interactively →