ACTR3B

Across TCGA cell cohorts, ACTR3B RNA expression is significantly associated with the go_rna of many other GO terms, with 5,218 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ACTR3B-associated GO terms across cancer lineages are Positive regulation of isotype switching to IgG isotypes, DNA-templated transcription termination, and XMP metabolic process. Each is linked with ACTR3B in more than 16 cancer types. Because this analysis shows association rather than direction, both ACTR3B-to-partner and partner-to-ACTR3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of isotype switching to IgG isotypes grouped by ACTR3B-low versus ACTR3B-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTR3B→partner) and Y-score (partner→ACTR3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Positive regulation of isotype switching to IgG isotypes →	+0.184	+1.254	<.001	<.001	3	17
BONE	DNA-templated transcription termination →	+0.121	+1.304	.001	<.001	3	16
BONE	XMP metabolic process →	+0.162	+1.362	.001	<.001	3	15
BONE	XMP biosynthetic process →	+0.162	+1.362	.001	<.001	3	15
BONE	'de novo' XMP biosynthetic process →	+0.162	+1.362	.001	<.001	3	15
SKIN	Regulation of isotype switching to IgG isotypes →	+0.137	+1.001	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,218 associations by consensus.

Positive regulation of isotype switching to IgG isotypes by ACTR3B expression — LUNG_NSCLC_LUSC

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