ACTR3B

Across TCGA cell cohorts, ACTR3B mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible ACTR3B-associated genes across cancer lineages are UBQLN3, OR13C4, and CCDC182. Each is linked with ACTR3B in more than 1 cancer types. Because this analysis shows association rather than direction, both ACTR3B-to-partner and partner-to-ACTR3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UBQLN3 grouped by ACTR3B-low versus ACTR3B-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTR3B→partner) and Y-score (partner→ACTR3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	UBQLN3 →	+0.029	+4.551	<.001	.004	3	2
LUNG_NSCLC_LUAD	OR13C4 →	+0.014	+3.887	<.001	.002	3	2
LARGE_INTESTINE	CCDC182 →	+0.073	+5.217	<.001	<.001	3	1
OVARY	XAGE5 →	+0.245	+5.196	<.001	.005	3	1
OVARY	OR7D4 →	+0.056	+5.196	<.001	.005	3	1
OVARY	OR10G2 →	+0.026	+5.196	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

UBQLN3 by ACTR3B expression — BLOOD_Leukemia

Explore this box plot interactively →