ACTR2

Across TCGA patient cohorts, ACTR2 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACTR2-associated genes across cancer lineages are MIG-6, ATM, and eEF2. Each is linked with ACTR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACTR2-to-partner and partner-to-ACTR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIG-6 grouped by ACTR2-low versus ACTR2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTR2→partner) and Y-score (partner→ACTR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIG-6 →	+0.080	+1.710	.035	.025	3	2
UCEC	ATM →	-0.673	-2.087	<.001	.005	3	2
UCEC	eEF2 →	+0.314	+1.678	.022	.023	3	1
UCEC	EGFR_pY1068 →	-0.266	-3.584	.005	.002	3	1
UCEC	A-Raf_pS299 →	-0.116	-2.321	.011	.033	3	1
UCEC	ERK2 →	+0.233	+2.222	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

MIG-6 by ACTR2 expression — UCEC

Explore this box plot interactively →