ACTR2

Across TCGA cell cohorts, ACTR2 mutation is significantly associated with the mutation status of many other genes, with 2,422 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ACTR2-associated genes across cancer lineages are PRKCH, TM9SF4, and DMPK. Each is linked with ACTR2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ACTR2-to-partner and partner-to-ACTR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRKCH grouped by ACTR2-low versus ACTR2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTR2→partner) and Y-score (partner→ACTR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PRKCH →	+4.479	+5.635	<.001	<.001	1	3
BLOOD_Leukemia	TM9SF4 →	+4.894	+4.894	.004	.004	1	3
BLOOD_Leukemia	DMPK →	+4.157	+5.430	<.001	<.001	1	3
LARGE_INTESTINE	VSIR →	+4.329	+4.329	.001	.001	1	3
BLOOD_Leukemia	CUEDC2 →	+5.894	+5.321	.002	.002	1	3
BLOOD_Leukemia	ASIC1 →	+4.309	+4.560	.007	.007	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,422 associations by consensus.

PRKCH by ACTR2 expression — BLOOD_Leukemia

Explore this box plot interactively →