ACTR1AP1

Across TCGA pan-cancer cohorts, ACTR1AP1 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated ACTR1AP1 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher ACTR1AP1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ACTR1AP1 expression acts as an unfavorable survival marker, although some lineages such as COAD and GBM show a favorable association.

UVM, DLBC, and LUAD are the cancer types where ACTR1AP1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	All	0.326	0.763	.003	45	view →
DLBC	DFS	Tertile	II,III,IV	0.330	0.951	<.001	36	view →
LUAD	DFS	Tertile	IV	0.435	0.822	.001	36	view →
COAD	OS	Median	III,IV	0.875	0.708	.001	32	view →
LIHC	DFS	Tertile	All	0.253	0.459	.001	30	view →
CHOL	DFS	Median	III,IV	0.127	0.647	.006	30	view →
ACC	OS	Quartile	All	0.211	0.669	.004	23	view →
KIRC	OS	Tertile	All	0.746	0.869	.002	22	view →
GBM	DFS	Quartile	All	0.466	0.216	.012	18	view →
UCS	OS	Tertile	IV	0.883	0.377	.024	18	view →
LUSC	OS	Tertile	All	0.724	0.805	.011	17	view →
BRCA	OS	Quartile	All	0.982	0.948	.004	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

ACTR1AP1–UVM (OS)

Open the UVM breakdown →