ACTR1A

Across TCGA patient cohorts, ACTR1A mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACTR1A-associated genes across cancer lineages are p62 Lck ligand, EGFR_pY1068, and A-Raf_pS299. Each is linked with ACTR1A in more than 1 cancer types. Because this analysis shows association rather than direction, both ACTR1A-to-partner and partner-to-ACTR1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by ACTR1A-low versus ACTR1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTR1A→partner) and Y-score (partner→ACTR1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.494	+3.817	<.001	<.001	3	2
UCEC	EGFR_pY1068 →	-0.209	-1.807	.044	.027	3	1
UCEC	A-Raf_pS299 →	-0.156	-2.321	.001	.034	3	1
UCEC	ACC1 →	+0.438	+3.183	.003	.009	3	1
UCEC	Ku80 →	+0.268	+1.884	.005	.030	3	1
UCEC	MEK1 →	+0.570	+3.906	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

p62 Lck ligand by ACTR1A expression — UCEC

Explore this box plot interactively →