ACTR10

Across TCGA patient cohorts, ACTR10 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACTR10-associated genes across cancer lineages are Fibronectin, p62 Lck ligand, and Rab11. Each is linked with ACTR10 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACTR10-to-partner and partner-to-ACTR10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fibronectin grouped by ACTR10-low versus ACTR10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTR10→partner) and Y-score (partner→ACTR10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Fibronectin →	-0.393	-3.459	.017	.005	3	1
UCEC	p62 Lck ligand →	+0.330	+2.817	.043	.036	3	1
UCEC	Rab11 →	-0.145	-2.321	.047	.035	3	1
UCEC	Annexin-1 →	+0.741	+3.189	.005	.010	3	1
UCEC	Rictor_pT1135 →	-0.108	-2.321	.035	.035	3	1
UCEC	Cyclin-B1 →	+0.757	+2.321	.007	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Fibronectin by ACTR10 expression — UCEC

Explore this box plot interactively →