ACTR10

Across TCGA cell cohorts, ACTR10 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ACTR10-associated genes across cancer lineages are C20orf141, OR7G2, and KRTAP21-2. Each is linked with ACTR10 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACTR10-to-partner and partner-to-ACTR10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C20orf141 grouped by ACTR10-low versus ACTR10-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTR10→partner) and Y-score (partner→ACTR10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	C20orf141 →	+0.106	+4.807	<.001	.006	3	1
BLOOD_Leukemia	OR7G2 →	+0.045	+5.201	<.001	.006	3	1
BLOOD_Leukemia	KRTAP21-2 →	+0.085	+5.539	<.001	.003	3	1
BLOOD_Leukemia	IQCF5 →	+0.135	+5.201	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

C20orf141 by ACTR10 expression — BLOOD_Myeloma

Explore this box plot interactively →