Q-omics provides the consensus-scored ACTP1 profile across patient tissues and cancer cell-line models. ACTP1 expression is associated with patient survival in 18 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, ACTP1 is differentially expressed in 5, with the highest sampling consensus in HNSC. Additionally, ACTP1 RNA expression shows 6,375 significant pathway-activity associations, with the highest sampling consensus in STAD. Together, these results highlight KIRC, HNSC, and STAD as cancer lineages where ACTP1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for ACTP1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes ACTP1 survival associations across molecular data types. ACTP1 RNA expression shows survival associations in the most cancer types (18). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible ACTP1 RNA expression–survival associations across cancer types. High ACTP1 expression shows unfavorable associations in KIRC, LIHC, DLBC, ACC and LUAD, but favorable associations in BLCA. The KIRC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .001). Together, the overview and detailed table identify KIRC as the clearest survival context for ACTP1 RNA expression.
This table summarizes ACTP1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 5. The strongest signals are observed in HNSC for RNA.
This table ranks reproducible tumor–normal expression differences for ACTP1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. ACTP1 shows higher tumor expression in HNSC, COAD, LUAD, LUSC and KIRP. The HNSC box plot shows higher ACTP1 RNA expression in tumor versus normal tissue (log2 FC = +0.291, t-test p = .009).
This table shows molecular features associated with ACTP1 in patient tissues and cancer cell lines. In patient samples, ACTP1 shows the broadest associations at the RNA and protein expression levels, with STAD recurring as the lineage with the largest associated feature set.
