ACTN4

Across TCGA pan-cancer cohorts, ACTN4 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated ACTN4 data layer compared with 25 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher ACTN4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ACTN4 expression acts as an unfavorable survival marker, although some lineages such as UCEC and STAD show a favorable association.

CESC, UCEC, and SKCM are the cancer types where ACTN4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Median	All	0.137	0.597	<.001	36	view →
UCEC	DFS	Median	All	0.969	0.624	.009	18	view →
SKCM	DFS	Median	II,III,IV	0.051	0.714	<.001	9	view →
BLCA	OS	Median	IV	0.198	0.607	.001	7	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
ESCA	OS	Median	All	0.084	0.685	<.001	6	view →
STAD	OS	Median	III,IV	1.000	0.433	.038	6	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

ACTN4–CESC (OS)

Open the CESC breakdown →