ACTN4

Across TCGA patient cohorts, ACTN4 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACTN4-associated genes across cancer lineages are Lck, Caspase-7-cleavedD198, and RBM15. Each is linked with ACTN4 in more than 2 cancer types. Because this analysis shows association rather than direction, both ACTN4-to-partner and partner-to-ACTN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lck grouped by ACTN4-low versus ACTN4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTN4→partner) and Y-score (partner→ACTN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Lck →	+0.166	+1.137	.008	.041	3	3
UCEC	Caspase-7-cleavedD198 →	+0.770	+2.999	<.001	<.001	3	3
STAD	RBM15 →	+0.496	+3.000	.030	.036	3	2
STAD	CD31 →	-0.209	-3.000	.009	.036	3	2
UCEC	Chk2_pT68 →	-0.174	-2.973	.002	<.001	3	2
UCEC	JNK2 →	+0.247	+1.933	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

Lck by ACTN4 expression — UCEC

Explore this box plot interactively →