ACTN4

Across TCGA cell cohorts, ACTN4 RNA expression is significantly associated with the RNA expression of many other genes, with 12,126 significant associations in total. CNS shows the largest number of these associations.

The most reproducible ACTN4-associated genes across cancer lineages are PAF1, NIBAN2, and AHNAK. Each is linked with ACTN4 in more than 16 cancer types. Because this analysis shows association rather than direction, both ACTN4-to-partner and partner-to-ACTN4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ACTN4 versus PAF1 in BREAST, with a Pearson correlation of 0.67.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTN4→partner) and Y-score (partner→ACTN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PAF1 →	+1.228	+1.453	<.001	<.001	3	17
BLOOD_Lymphoma	NIBAN2 →	+2.891	+1.495	<.001	<.001	3	17
BONE	AHNAK →	+2.323	+1.595	<.001	<.001	3	16
URINARY_TRACT	RBM42 →	+1.307	+1.883	<.001	<.001	3	16
BONE	LMNA →	+2.481	+1.639	<.001	<.001	3	16
LARGE_INTESTINE	PLEC →	+1.945	+1.237	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,126 associations by consensus.

ACTN4 vs PAF1 — BREAST

Explore this scatter interactively →