ACTN4

Across TCGA cell cohorts, ACTN4 mutation is significantly associated with the RNA expression of many other genes, with 68 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ACTN4-associated genes across cancer lineages are GPRIN2, ELOA3CP, and OTOR. Each is linked with ACTN4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACTN4-to-partner and partner-to-ACTN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPRIN2 grouped by ACTN4-low versus ACTN4-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTN4→partner) and Y-score (partner→ACTN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GPRIN2 →	+0.032	+4.004	<.001	.002	3	2
BLOOD_Leukemia	ELOA3CP →	+0.152	+3.789	<.001	.002	3	2
URINARY_TRACT	OTOR →	+0.030	+5.087	<.001	.004	3	1
URINARY_TRACT	PRAMEF9 →	+0.013	+5.087	<.001	.004	3	1
BLOOD_Leukemia	PHOX2B →	+0.013	+3.365	.006	.005	3	1
BLOOD_Leukemia	NUDT10 →	+1.095	+3.491	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 68 associations by consensus.

GPRIN2 by ACTN4 expression — BLOOD_Leukemia

Explore this box plot interactively →