ACTN3

Across TCGA patient cohorts, ACTN3 RNA expression is significantly associated with the protein abundance of many other proteins, with 7,040 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ACTN3-associated proteins across cancer lineages are OLFML1, OSBPL3_S304, and S100A11_S6. Each is linked with ACTN3 in more than 2 cancer types. Because this analysis shows association rather than direction, both ACTN3-to-partner and partner-to-ACTN3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ACTN3 versus OLFML1 in PDAC, with a Pearson correlation of 0.35.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTN3→partner) and Y-score (partner→ACTN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	OLFML1 →	+0.591	+0.104	<.001	.001	3	3
GBM	OSBPL3_S304 →	-0.496	-0.250	.001	.003	3	3
GBM	S100A11_S6 →	-0.602	-0.214	<.001	<.001	3	3
GBM	HDGFL3 →	+0.395	+0.281	<.001	<.001	3	3
GBM	CD63 →	-0.601	-0.278	<.001	<.001	3	3
BRCA	GALNT7 →	-0.417	-0.121	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,040 associations by consensus.

ACTN3 vs OLFML1 — PDAC

Explore this scatter interactively →