ACTN3

Across TCGA patient cohorts, ACTN3 protein abundance is significantly associated with the RNA expression of many other genes, with 6,969 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible ACTN3-associated genes across cancer lineages are PDE1A, SYNE1, and LMOD1. Each is linked with ACTN3 in more than 4 cancer types. Because this analysis shows association rather than direction, both ACTN3-to-partner and partner-to-ACTN3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ACTN3 versus PDE1A in COAD, with a Pearson correlation of 0.55.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTN3→partner) and Y-score (partner→ACTN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PDE1A →	+1.116	+0.799	<.001	<.001	3	5
UCEC	SYNE1 →	+0.769	+0.460	<.001	.002	3	5
COAD	LMOD1 →	+1.377	+0.525	<.001	<.001	3	5
UCEC	MAMDC2 →	+1.265	+0.704	.003	.003	3	5
COAD	FBN1 →	+1.303	+0.727	.001	<.001	3	5
HNSC	HSPB7 →	+2.573	+1.114	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,969 associations by consensus.

ACTN3 vs PDE1A — COAD

Explore this scatter interactively →